An Update on 2,5-Diketopiperazines from Marine Organisms

Marine Drugs

Ri-Ming Huang¹  Xiang-Xi Yi³  Yuying Zhou⁴  Xiangdong Su²  Yan Peng⁶  Cheng-Hai Gao⁵ 

[1] Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China; E-Mail:;Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK; E-Mail:;School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China; E-Mail:;Department of Cell Biology, Jinan University, Guangzhou 510632, China; E-Mail:;Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning 530007, China;Life Science & Technology School, Lingnan Normal University, Zhanjiang 52048, China; E-Mail:

关键词: 2;    5-diketopiperazine;    marine organism;    biosynthetic processes;    biological activity;   

DOI  :  10.3390/md12126213

来源: mdpi

【 摘 要 】

2,5-Diketopiperazines (2,5-DKPs) are an important category of structurally diverse cyclic dipeptides with prominent biological properties. These 2,5-DKPs have been obtained from a variety of natural resources, including marine organisms. Because of the increasing numbers and biological importance of these compounds, this review covers 90 marine originated 2,5-DKPs that were reported from 2009 to the first half-year of 2014. The review will focus on the structure characterizations, biological properties and proposed biosynthetic processes of these compounds.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.