International Journal of Molecular Sciences | |
Chitosan Improves Anti-Biofilm Efficacy of Gentamicin through Facilitating Antibiotic Penetration | |
Haibo Mu1  Fan Guo1  Hong Niu1  Qianjin Liu1  Shunchun Wang2  Jinyou Duan1  | |
[1]College of Science, Northwest A&F University, Yangling 712100, China | |
[2] E-Mails: | |
[3]The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China | |
关键词: chitosan; antibiotic; biofilms; penetration; | |
DOI : 10.3390/ijms151222296 | |
来源: mdpi | |
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【 摘 要 】
Antibiotic overuse is one of the major drivers in the generation of antibiotic resistant “super bugs” that can potentially cause serious effects on health. In this study, we reported that the polycationic polysaccharide, chitosan could improve the efficacy of a given antibiotic (gentamicin) to combat bacterial biofilms, the universal lifestyle of microbes in the world. Short- or long-term treatment with the mixture of chitosan and gentamicin resulted in the dispersal of
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
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