Two New N-Oxide Alkaloids from Stemona cochinchinensis

Molecules

Ligen Lin¹  Han Bao¹  Anqi Wang¹  Chunping Tang²  Pham-Huu Dien³  Yang Ye² 

[1] State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China; E-Mails:;State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; E-Mail:;Department of Organic Chemistry, Faculty of Chemistry, Hanoi National University of Education, Hanoi 100000, Vietnam; E-Mail:

关键词: Stemona cochinchinensis;    Stemonaceae;    N-oxide alkaloids;    ¹H- and ¹³C-NMR;    anti-tussive activity;   

DOI  :  10.3390/molecules191220257

来源: mdpi

【 摘 要 】

Two new N-oxide alkaloids with pyrrolo[1,2-α]azepine skeleton, namely isoneostemocochinine-N-oxide (1) and neostemocochinine-N-oxide (2), as well as three known alkaloids with pyrido[1,2-α]azepine skeletons, were isolated and identified from the roots of Stemona cochinchinensis (Stemonaceae). The structures of these compounds were elucidated by 1D- and 2D-NMR spectra and other spectroscopic studies. Additionally, the ¹H- and ¹³C-NMR characteristic of N-oxide Stemona alkaloids was summarized. Stemokerrin showed potent anti-tussive activity on citric acid-induced guinea pig model.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.