Reaction of Substituted Furan-2-carboxaldehydes and Furo[b]pyrrole Type Aldehydes with Hippuric Acid

Molecules

 Zita Puterová²  Heinz Sterk¹ 

[1] Institute of Chemistry, Karl-Franzens University of Graz, A-8010 Graz, Austria.;Department of Chemistry, Faculty of Natural Sciences, University of St. Cyril and Methodius in Trnava, SK-917 01 Trnava, Slovak Republic, Tel. [phone], Fax [phone].

关键词: 5-Arylfuran-2-carboxaldehydes;    furo[3;    2-b]pyrrole-2-carboxaldehydes;    furo-[2;    3-b]pyrrole-2-carboxaldehydes;    hippuric acid;    microwave irradiation;    1;    3-oxazol-5(4H)-ones;    furo[3;    2-b]pyrrole-5-carboxylates;    furo[2;    3-b]pyrrole-5-carboxylates;    ¹H- and ¹³C-NMR;    COSY;    NOESY;    HSQC;    HMBC;   

DOI  :  10.3390/90100011

来源: mdpi

【 摘 要 】

4-Heteroarylidene-2-phenyl-1,3-oxazol-5(4H)-ones were prepared by reactions of hippuric acid with substituted furan-2-carboxaldehydes or furo[b]pyrrole type aldehydes. The reactivity of various furan-2-carboxaldehyde derivatives in this reaction is discussed. The effect of microwave irradiation on some condensation reactions was compared with “classical” conditions. The results show that microwave irradiation shortens the reaction times while affording comparable yields. Elementary analysis, UV, IR and 1D NMR proved the structure of new synthesised compounds. 2D NMR spectroscopic measurements confirmed that the configuration at the carbon-carbon double bond corresponds to the pure E isomers of the products.

【 授权许可】

Unknown   
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