Resveratrol Inhibits Trophoblast Apoptosis through Oxidative Stress in Preeclampsia-Model Rats

Molecules

Yanfen Zou²  Qing Zuo²  Shiyun Huang²  Xiang Yu¹  Ziyan Jiang²  Shan Zou²  Mingsong Fan²  Lizhou Sun² 

[1] Department of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan Road, Xiaguan District, Nanjing 210000, Jiangsu, China; E-Mail:;Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu, China; E-Mails:

关键词: resveratrol;    HTR-8/SVneo cells;    oxidative stress;    apoptosis;   

DOI  :  10.3390/molecules191220570

来源: mdpi

【 摘 要 】

Resveratrol has been shown to be a therapeutic agent for cardiovascular disorders by maintaining a lower redox level in vivo through its anti-oxidant properties. Resveratrol can prevent cells from p53- and reactive oxygen species-dependent apoptosis induced by interleukin-1b. We identified an inhibitory effect of resveratrol against oxidative stress and apoptosis using the TUNEL assay in NG-Nitro-l-arginine methyl ester-induced preeclampsia in rats. To investigate a possible association between resveratrol and the apoptosis caused by oxidative stress in vitro, assays for superoxide dismutase and malondialdehyde as well as flow cytometric analyses were conducted in HTR-8/SVneo cells after hypoxic treatment with or without resveratrol for 24 h. These data suggest that resveratrol significantly opposes the effects of oxidative stress in vivo and in vitro.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.