Insights from Space: Potential Role of Diet in the Spatial Organization of Chromosomes

Nutrients

Justin M. O’Sullivan²  Malina D. Doynova²  Jisha Antony¹  Florian Pichlmuller² 

[1]Department of Pathology, Dunedin School of Medicine, The University of Otago, P.O. Box 913, Dunedin 9054, New Zealand

[2] E-Mails:

[3]The Liggins Institute, The University of Auckland, Private Bag 92019 AMC, Auckland 1142, New Zealand

[4] E-Mails:

关键词: HiC;    proximity ligation;    genome organization;    nutrition;    epigenetics;    estrogen;    cohesion;    CTCF;   

DOI  :  10.3390/nu6125724

来源: mdpi

【 摘 要 】

We can now sequence and identify genome wide epigenetic patterns and perform a variety of “genomic experiments” within relatively short periods of time—ranging from days to weeks. Yet, despite these technological advances, we have a poor understanding of the inter-relationships between epigenetics, genome structure-function, and nutrition. Perhaps this limitation lies, in part, in our propensity to study epigenetics in terms of the linear arrangement of elements and genes. Here we propose that a more complete understanding of how nutrition impacts on epigenetics and cellular development resides within the inter-relationships between DNA and histone modification patterns and genome function, in the context of spatial organization of chromatin and the epigenome.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.