Marine Sponge Lectins: Actual Status on Properties and Biological Activities

Molecules

Sandro Mascena Gomes Filho³  Juscélio Donizete Cardoso³  Katya Anaya¹  Edilza Silva do Nascimento³  José Thalles Jucelino Gomes de Lacerda³  Roberto Mioso²  Tatiane Santi Gadelha³  Carlos Alberto de Almeida Gadelha³ 

[1] Faculdade de Ciências da Saúde do Trairi, Universidade Federal do Rio Grande do Norte, Centro, Santa Cruz, RN CEP 5900000, Brazil;Núcleo de Engenharia de Pesca, Universidade Federal de Sergipe, Avenida Marechal Rondon, s/nº, São Cristóvão, SE CEP 49100000, Brazil;Laboratório de Proteômica Estrutural, Departamento de Biologia Molecular, Universidade Federal da Paraíba, Cidade Universitária, João Pessoa, PB CEP 58059-900, Brazil

关键词: marine sponge;    lectins;    properties;    biological activities;   

DOI  :  10.3390/molecules20010348

来源: mdpi

【 摘 要 】

Marine sponges are primitive metazoans that produce a wide variety of molecules that protect them against predators. In studies that search for bioactive molecules, these marine invertebrates stand out as promising sources of new biologically-active molecules, many of which are still unknown or little studied; thus being an unexplored biotechnological resource of high added value. Among these molecules, lectins are proteins that reversibly bind to carbohydrates without modifying them. In this review, various structural features and biological activities of lectins derived from marine sponges so far described in the scientific literature are discussed. From the results found in the literature, it could be concluded that lectins derived from marine sponges are structurally diverse proteins with great potential for application in the production of biopharmaceuticals, especially as antibacterial and antitumor agents.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.