Nutrients | |
Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-Analysis | |
Boyi Yang2  Shujun Fan2  Xueyuan Zhi2  Yinuo Wang1  Yanxun Wang1  Quanmei Zheng2  | |
[1] Division of Molecular Preventive Medicine, Shanghai Institute of Targeted Therapy and Molecular Medicine, Shanghai 200433, China; E-Mails:;Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110013, China; E-Mails: | |
关键词: hyperhomocysteinemia; prevalence; China; meta-analysis; | |
DOI : 10.3390/nu7010074 | |
来源: mdpi | |
【 摘 要 】
Hyperhomocysteinemia (HHcy, total homocysteine concentrations > 15 μmol/L) has been associated with increased risk of many diseases. A systematic review was performed to summarize the prevalence of HHcy in China. We searched multiple international and Chinese scientific databases for relevant literature, and further manually screened reference lists and corresponded with original authors. Pooled prevalence of HHcy was calculated using random effects model. Subgroup analysis, meta-regression and sensitivity analysis were also performed. A total of 36 studies consisting 60,754 subjects (57.3% male; age range, 3–97 years) were finally included. The overall pooled prevalence of HHcy was 27.5%. Geographically, the prevalence was high in north areas, intermediate in central areas, and low in south areas, and was higher in inland
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190018043ZK.pdf | 740KB | download |