International Journal of Molecular Sciences | |
Motor, Visual and Emotional Deficits in Mice after Closed-Head Mild Traumatic Brain Injury Are Alleviated by the Novel CB2 Inverse Agonist SMM-189 | |
Anton Reiner1  Scott A. Heldt1  Chaela S. Presley2  Natalie H. Guley1  Andrea J. Elberger1  Yunping Deng1  Lauren D’Surney1  Joshua T. Rogers1  Jessica Ferrell1  Wei Bu1  Nobel Del Mar1  Marcia G. Honig1  Steven N. Gurley2  Bob M. Moore2  | |
[1] Department of Anatomy and Neurobiology, the University of Tennessee Health Science Center, Memphis, TN 38163, USA; E-Mails:;Department of Pharmaceutical Sciences, the University of Tennessee Health Science Center, Memphis, TN 38163, USA; E-Mails: | |
关键词: TBI; deficits; microglia; CB2 receptors; therapy; | |
DOI : 10.3390/ijms16010758 | |
来源: mdpi | |
【 摘 要 】
We have developed a focal blast model of closed-head mild traumatic brain injury (TBI) in mice. As true for individuals that have experienced mild TBI, mice subjected to 50–60 psi blast show motor, visual and emotional deficits, diffuse axonal injury and microglial activation, but no overt neuron loss. Because microglial activation can worsen brain damage after a concussive event and because microglia can be modulated by their cannabinoid type 2 receptors (CB2), we evaluated the effectiveness of the novel CB2 receptor inverse agonist SMM-189 in altering microglial activation and mitigating deficits after mild TBI.
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
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