International Journal of Molecular Sciences | |
Pathogenesis of Target Organ Damage in Hypertension: Role of Mitochondrial Oxidative Stress | |
Speranza Rubattu1  Beniamino Pagliaro1  Giorgia Pierelli1  Caterina Santolamazza1  Sara Di Castro2  Silvia Mennuni1  Massimo Volpe1  | |
[1] Department of Clinical and Molecular Medicine, School of Medicine and Psychology, University Sapienza of Rome, Ospedale S. Andrea, Rome 00189, Italy; E-Mails:;Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Neuromed, Pozzilli 86077, Italy; E-Mail: | |
关键词: target organ damage; hypertension; mitochondrial dysfunction; oxidative stress; | |
DOI : 10.3390/ijms16010823 | |
来源: mdpi | |
【 摘 要 】
Hypertension causes target organ damage (TOD) that involves vasculature, heart, brain and kidneys. Complex biochemical, hormonal and hemodynamic mechanisms are involved in the pathogenesis of TOD. Common to all these processes is an increased bioavailability of reactive oxygen species (ROS). Both
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190017954ZK.pdf | 1200KB | download |