Cardiac and Vascular Target Organ Damage in Pediatric Hypertension

Frontiers in Pediatrics

Michael Khoury¹ 

关键词: echocardiography;    vascular function;    target organ damage;    hypertension;    left ventricular mass;    cardiac function;   

DOI  :  10.3389/fped.2018.00148

学科分类：儿科学

来源: Frontiers

【 摘 要 】

Atherosclerosis begins in youth and is associated with the presence of numerous modifiable cardiovascular (CV) risk factors, including hypertension. Pediatric hypertension has increased in prevalence since the 1980s but has plateaued in recent years. Elevated blood pressure levels are associated with impairments to cardiac and vascular structure and both systolic and diastolic function. Blood pressure-related increases in left ventricular mass (LVM) and abnormalities in cardiac function are associated with hard CV events in adulthood. In addition to cardiac changes, key vascular changes occur in hypertensive youth and adults. These include thickening of the arteries, increased arterial stiffness, and decreased endothelial function. This review summarizes the epidemiologic burden of pediatric hypertension, its associations with target organ damage (TOD) of the cardiac and vascular systems, and the impact of these adverse CV changes on morbidity and mortality in adulthood.

【 授权许可】

CC BY