Lectins with Anti-HIV Activity: A Review

Molecules

Ouafae Akkouh²  Tzi Bun Ng³  Senjam Sunil Singh¹  Cuiming Yin³  Xiuli Dan³  Yau Sang Chan³  Wenliang Pan³  Randy Chi Fai Cheung³ 

[1] Department of Biochemistry, Manipur University, Canchipur, Imphal 795003, India; E-Mail:;Department of Biology and Medical Laboratory Research, Faculty of Technology, University of Applied Sciences Leiden, Zernikdreef 11, 2333 CK Leiden, The Netherlands; E-Mail:;School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China; E-Mails:

关键词: lectins;    anti-HIV;    worm;    cyanobacteria;    actinomycete;   

DOI  :  10.3390/molecules20010648

来源: mdpi

【 摘 要 】

Lectins including flowering plant lectins, algal lectins, cyanobacterial lectins, actinomycete lectin, worm lectins, and the nonpeptidic lectin mimics pradimicins and benanomicins, exhibit anti-HIV activity. The anti-HIV plant lectins include Artocarpus heterophyllus (jacalin) lectin, concanavalin A, Galanthus nivalis (snowdrop) agglutinin-related lectins, Musa acuminata (banana) lectin, Myrianthus holstii lectin, Narcissus pseudonarcissus lectin, and Urtica diocia agglutinin. The anti-HIV algal lectins comprise Boodlea coacta lectin, Griffithsin, Oscillatoria agardhii agglutinin. The anti-HIV cyanobacterial lectins are cyanovirin-N, scytovirin, Microcystis viridis lectin, and microvirin. Actinohivin is an anti-HIV actinomycete lectin. The anti-HIV worm lectins include Chaetopterus variopedatus polychaete marine worm lectin, Serpula vermicularis sea worm lectin, and C-type lectin Mermaid from nematode (Laxus oneistus). The anti-HIV nonpeptidic lectin mimics comprise pradimicins and benanomicins. Their anti-HIV mechanisms are discussed.

【 授权许可】

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