Marine Drugs | |
Chitosan in Mucoadhesive Drug Delivery: Focus on Local Vaginal Therapy | |
Toril Andersen2  Stefan Bleher2  Gøril Eide Flaten2  Ingunn Tho3  Sofia Mattsson4  Nataᘚ Škalko-Basnet2  David Harding1  | |
[1] Drug Transport and Delivery Research Group, Department of Pharmacy, Faculty of Health Sciences, University of Tromsø The Arctic University of Norway, Tromsø 9037, Norway;;Drug Transport and Delivery Research Group, Department of Pharmacy, Faculty of Health Sciences, University of Tromsø The Arctic University of Norway, Tromsø 9037, Norway; E-Mails:;PharmaLuxLab Research Group, School of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Oslo, 0316 Oslo, Norway; E-Mail:;Department of Pharmacology and Clinical Neuroscience, Division of Clinical Pharmacology, Umeå University, Umeå SE-90187, Sweden; E-Mail: | |
关键词: chitosan; drug delivery; mucoadhesion; vaginal therapy; FITC-dextran; | |
DOI : 10.3390/md13010222 | |
来源: mdpi | |
【 摘 要 】
Mucoadhesive drug therapy destined for localized drug treatment is gaining increasing importance in today’s drug development. Chitosan, due to its known biodegradability, bioadhesiveness and excellent safety profile offers means to improve mucosal drug therapy. We have used chitosan as mucoadhesive polymer to develop liposomes able to ensure prolonged residence time at vaginal site. Two types of mucoadhesive liposomes, namely the chitosan-coated liposomes and chitosan-containing liposomes, where chitosan is both embedded and surface-available, were made of soy phosphatidylcholine with entrapped fluorescence markers of two molecular weights, FITC-dextran 4000 and 20,000, respectively. Both liposomal types were characterized for their size distribution, zeta potential, entrapment efficiency and the
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190017799ZK.pdf | 392KB | download |