On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture

Molecules

Tania K. Lind¹  Piotr Polcyn²  Paulina Zielinska²  Marité Cárdenas¹  Zofia Urbanczyk-Lipkowska² 

[1] Nano-Science Center and Department of Chemistry, University of Copenhagen, Copenhagen 2100, Denmark; E-Mail:;Institute of Organic Chemistry, Polish Academy of Science, Warsaw 01-224, Poland; E-Mails:

关键词: dendrimers;    peptide;    antimicrobial;    lipids;   

DOI  :  10.3390/molecules20010738

来源: mdpi

【 摘 要 】

Antimicrobial drug resistance is a major human health threat. Among the many attempts to tackle this problem, the synthesis of antimicrobial compounds that mimic natural antimicrobial peptides appears as a promising approach. Peptide-based dendrimers can be designed to have higher potency than natural antimicrobial peptides and at the same time they can evade the bacterial defense system. Novel dendrimers with similar chemical structure but varying potency in terms of minimum inhibitory concentration were designed. The dependency between dendrimer structure and antibacterial activity as well as their capacity to attack model cell membranes was studied. The data suggests that supramolecular structure in terms of charge distribution and amphiphilicity, rather than net charge, is the main driver for disruption of cellular membranes and this correlates well with dendrimer hemolytic activity.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.