Development of New 1,3-Diazaphenoxazine Derivatives (ThioG-Grasp) to Covalently Capture 8-Thioguanosine

Molecules

Yasufumi Fuchi²  Hideto Obayashi²  Shigeki Sasaki¹ 

[1] Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan;

关键词: oxidative damage;    oxidized nucleoside;    8-oxoguanosine;    8-nitroguanosine;    8-thioguanosine;   

DOI  :  10.3390/molecules20011078

来源: mdpi

【 摘 要 】

The derivatives of 8-thioguanosine are thought to be included in the signal transduction system related to 8-nitroguanosine. In this study, we attempted to develop new 1,3-diazaphenoxazine (G-clamp) derivatives to covalently capture 8-thioguanosine (thioG-grasp). It was expected that the chlorine atom at the end of the linker would be displaced by the nucleophilic attack by the sulfur atom of 8-thioguanosine via multiple hydrogen-bonded complexes. The thioG-grasp derivative with a propyl linker reacted efficiently with 8-thioguanosine to form the corresponding adduct.

【 授权许可】

CC BY   
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