Nitric Oxide-Induced Nitrative Stress Involved in Microbial Pathogenesis

Journal of Pharmacological Sciences

Takaaki Akaike¹  Mohammad Hasan Zaki¹  Teruo Akuta¹ 

[1] Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University

关键词: nitric oxide;    peroxynitrite;    nitrative stress;    8-nitroguanosine;    viral pathogenesis;    viral mutation;   

DOI  :  10.1254/jphs.CRJ05004X

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(100)Cited-By(48)The pathogenic mechanism of infections is a complicated but important scientific theme that is now attracting great attention because of its association with host-derived as well as microbial factors. Recent advances in free radical research revealed that reactive oxygen and nitrogen oxide species such as superoxide (O2−) and nitric oxide (NO) play a leading role in the pathogenesis of infections caused by viral pathogens including influenza virus and other RNA viruses. Although NO and O2− have antimicrobial activity against bacteria, fungi, and parasites, in some viral infections they have an opposite effect. This exacerbation caused by NO and O2− is mediated by reactive nitrogen oxides, for example, peroxynitrite (ONOO−), generated by reaction of NO with O2−. These nitrogen oxides have strong oxidation and nitration potential and can modify biological molecules, thereby creating oxidative and nitrative stress that contributes to pathogenic processes during viral infection. Nitrative stress-mediated 8-nitroguanosine formation during influenza or Sendai virus infection has been the focus of enormous interest because it involves unique biochemical and pharmacological properties such as redox activity and mutagenic potential. In this review, we discuss the nature and impact of nitrative stress in viral infection, with emphasis on nitrative stress-mediated viral pathogenesis, which we have recently been investigating.

【 授权许可】

Unknown