An Alkaloid and a Steroid from the Endophytic Fungus Aspergillus fumigatus

Molecules

Zizhen Liang²  Tiantian Zhang²  Xiaoqian Zhang²  Jia Zhang²  Changqi Zhao¹ 

[1] Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Science, Beijing Normal University, Beijing 100875, China;

关键词: Diphylleia sinensis L;    Aspergillus fumigates;    indolediketopiperazine alkaloids;    steroid;    cytotoxicity;   

DOI  :  10.3390/molecules20011424

来源: mdpi

【 摘 要 】

Two new compounds, fumitremorgin 12-methoxy-13-[5'-hydroxy-2'-(1''-hydroxy-3''-methoxy-5''-methylbenzoyl)-3'-methoxy]benzoic acid methyl ester (fumitremorgin D, 1) and 4,8,10,14-tetramethyl-6-acetoxy-14-[16-acetoxy-19-(20,21-dimethyl)-18-ene]-phenanthrene-1-ene-3,7-dione (2) were isolated from the cultured endophytic isolated fungus Aspergillus fumigatus, together with fourteen known compounds. Their structures were elucidated by 1-D and 2-D NMR analyses. The cytotoxicity profile of the compound against the human hepatocellular carcinoma cell line HepG2 was evaluated by MTT antiproliferative assays.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.