The Potential of Minor Ginsenosides Isolated from the Leaves of Panax ginseng as Inhibitors of Melanogenesis

International Journal of Molecular Sciences

Dae-Young Lee²  Byeong-Ju Cha¹  Young-Seob Lee²  Geum-Soog Kim²  Hyung-Jun Noh²  Seung-Yu Kim²  Hee Cheol Kang³  Jin Hee Kim⁴  Nam-In Baek¹ 

[1] Graduate School of Oriental Medicine Biotechnology, Kyung Hee University, Yongin 446-706, Korea; E-Mail:;Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 369-837, Korea; E-Mails:;Research & Development Center, GFC Co., Ltd., Suwon 443-813, Korea; E-Mail:;College of Herbal Bio-industry, Daegu Haany University, Gyeongsan 712-715, Korea

关键词: Panax ginseng;    melanogenesis;    NMR;    vina-ginsenoside;   

DOI  :  10.3390/ijms16011677

来源: mdpi

【 摘 要 】

Three minor ginsenosides, namely, ginsenoside Rh6 (1), vina-ginsenoside R4 (2) and vina-ginsenoside R13 (3), were isolated from the leaves of hydroponic Panax ginseng. The chemical structures were determined based on spectroscopic methods, including fast atom bombardment mass spectroscopy (FAB-MS), 1D-nuclear magnetic resonance (NMR), 2D-NMR, and, infrared (IR) spectroscopy. The melanogenic inhibitory activity of compounds 1, 2 and 3 was 23.9%, 27.8% and 35.2%, respectively, at a concentration of 80 µM. Likewise, the three compounds showed inhibitory activity on body pigmentation on a zebrafish model, which is commonly used as a model for biomedical or cosmetic research. These results from in vitro and in vivo systems suggest that the three aforementioned compounds isolated from Panax ginseng may have potential as new skin whitening compounds.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.