期刊论文详细信息
Molecules
Deoxypodophyllotoxin Induces G2/M Cell Cycle Arrest and Apoptosis in SGC-7901 Cells and Inhibits Tumor Growth in Vivo
Yu-Rong Wang1  Yuan Xu1  Zhen-Zhou Jiang1  Mounia Guerram1  Bin Wang1  Xiong Zhu2  Lu-Yong Zhang1 
[1] Jiangsu Center for Drug Screening, China Pharmaceutical University, Nanjing 210009, China; E-Mails:;Medical and Chemical Institute, China Pharmaceutical University, Nanjing 210009, China; E-Mail:
关键词: deoxypodophyllotoxin;    human gastric cancer;    cell cycle arrest;    apoptosis;    anti-angiogenesis;   
DOI  :  10.3390/molecules20011661
来源: mdpi
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【 摘 要 】

Deoxypodophyllotoxin (DPT), a natural microtubule destabilizer, was isolated from Anthriscus sylvestris, and a few studies have reported its anti-cancer effect. However, the in vivo antitumor efficacy of DPT is currently indeterminate. In this study, we investigated the anti-gastric cancer effects of DPT both in vitro and in vivo. Our data showed that DPT inhibited cancer cell proliferation and induced G2/M cell cycle arrest accompanied by an increase in apoptotic cell death in SGC-7901 cancer cells. In addition, DPT caused cyclin B1, Cdc2 and Cdc25C to accumulate, decreased the expression of Bcl-2 and activated caspase-3 and PARP, suggesting that caspase-mediated pathways were involved in DPT-induced apoptosis. Animal studies revealed that DPT significantly inhibited tumor growth and decreased microvessel density (MVD) in a xenograft model of gastric cancer. Taken together, our findings provide a framework for further exploration of DPT as a novel chemotherapeutic for human gastric cancer.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.

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