Marine Structure Derived Calcium Phosphate–Polymer Biocomposites for Local Antibiotic Delivery

Marine Drugs

Innocent J. Macha²  Sophie Cazalbou³  Besim Ben-Nissan²  Kate L. Harvey⁴  Bruce Milthorpe¹ 

[1] Faculty of Science, University of Technology Sydney, Broadway NSW 2007, Australia; E-Mail:;School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia; E-Mail:;CIRIMAT Carnot Institute, CNRS-INPT-UPS, University of Toulouse, 31030 Toulouse, France; E-Mail:;The ithree Institute, Faculty of Science, University of Technology Sydney, Broadway NSW 2007, Australia; E-Mail:

关键词: drug release;    thin film composites;    coral;    hydroxyapatite;    microbial adhesion;    S. aureus;   

DOI  :  10.3390/md13010666

来源: mdpi

【 摘 要 】

Hydrothermally converted coralline hydroxyapatite (HAp) particles loaded with medically active substances were used to develop polylactic acid (PLA) thin film composites for slow drug delivery systems. The effects of HAp particles within PLA matrix on the gentamicin (GM) release and release kinetics were studied. The gentamicin release kinetics seemed to follow Power law Korsmeyer Peppas model with mainly diffusional process with a number of different drug transport mechanisms. Statistical analysis shows very significant difference on the release of gentamicin between GM containing PLA (PLAGM) and GM containing HAp microspheres within PLA matrix (PLAHApGM) devices, which PLAHApGM displays lower release rates. The use of HAp particles improved drug stabilization and higher drug encapsulation efficiency of the carrier. HAp is also the source of Ca²⁺ for the regeneration and repair of diseased bone tissue. The release profiles, exhibited a steady state release rate with significant antimicrobial activity against Staphylococcus aureus (S. aureus) (SH1000) even at high concentration of bacteria. The devices also indicated significant ability to control the growth of bacterial even after four weeks of drug release. Clinical release profiles can be easily tuned from drug-HAp physicochemical interactions and degradation kinetics of polymer matrix. The developed systems could be applied to prevent microbial adhesion to medical implant surfaces and to treat infections mainly caused by S. aureus in surgery.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.