Antibacterial Poly(ε-CL)/Hydroxyapatite Electrospun Fibers Reinforced by Poly(ε-CL)-b-poly(ethylene phosphoric acid)

International Journal of Molecular Sciences

Alexander Tavtorkin¹  Dmitry Gavrilov¹  Victoria Besprozvannykh¹  Pavel Komarov¹  Pavel Ivchenko¹  Ilya Nifant’ev¹  Maria Chinova¹  Irina Podoprigora²  Vladimir Zaitsev³ 

[1] A.V. Topchiev Institute of Petrochemical Synthesis RAS, Leninsky Pr. 29, 119991 Moscow, Russia;Department of Microbiology and Virology, Institute of Medicine, RUDN University, 8 Miklukho-Maklaya Str. 8, 117198 Moscow, Russia;Priorov Central Institute for Trauma and Orthopedics, Priorova Str. 10, 127299 Moscow, Russia;

关键词: poly(ε-caprolactone);    drug release;    electrospinning;    hydroxyapatite;    nanofibers;    nanoparticles;   

DOI  :  10.3390/ijms22147690

来源: DOAJ

【 摘 要 】

In bone surgery and orthopedics, bioresorbable materials can be helpful in bone repair and countering post-op infections. Explicit antibacterial activity, osteoinductive and osteoconductive effects are essential to achieving this objective. Nonwoven electrospun (ES) fibers are receiving the close attention of physicians as promising materials for wound dressing and tissue engineering; potentially, in high contrast with dense materials, ES mats hamper regeneration of the bone extracellular matrix to a lesser extent. The use of the compositions of inherently biodegradable polyesters (poly(ε-caprolactone) PCL, poly(lactoglycolide), etc.), calcium phosphates and antibiotics is highly prospective, but the task of forming ES fibers from such compositions is complicated by the incompatibility of the main organic and inorganic ingredients, polyesters and calcium phosphates. In the present research we report the synthesis of hydroxyapatite (HAp) nanoparticles with uniform morphology, and demonstrate high efficiency of the block copolymer of PCL and poly(ethylene phosphoric acid) (PEPA) as an efficient compatibilizer for PCL/HAp mixtures that are able to form ES fibers with improved mechanical characteristics. The materials obtained in the presence of vancomycin exhibited incremental drug release against Staphylococcus aureus (St. aureus).

【 授权许可】

Unknown