Extracellular Molecules Involved in Cancer Cell Invasion

Cancers

Theodora Stivarou¹  Evangelia Patsavoudi¹ 

[1] Department of Biochemistry, Hellenic Pasteur Institute, Athens 11521, Greece

关键词: cell invasion;    metastasis;    cell surface;    extracellular;   

DOI  :  10.3390/cancers7010238

来源: mdpi

【 摘 要 】

Nowadays it is perfectly clear that understanding and eradicating cancer cell invasion and metastasis represent the crucial, definitive points in cancer therapeutics. During the last two decades there has been a great interest in the understanding of the extracellular molecular mechanisms involved in cancer cell invasion. In this review, we highlight the findings concerning these processes, focusing in particular on extracellular molecules, including extracellular matrix proteins and their receptors, growth factors and their receptors, matrix metalloproteinases and extracellular chaperones. We report the molecular mechanisms underlying the important contribution of this pool of molecules to the complex, multi-step phenomenon of cancer cell invasion.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.