From Formamide to RNA, the Path Is Tenuous but Continuous

Life

Samanta Pino¹  Judit E. Sponer⁴  Giovanna Costanzo²  Raffaele Saladino³  Ernesto Di Mauro¹ 

[1] Fondazione “Istituto Pasteur-Fondazione Cenci-Bolognetti” c/o Dipartimento di Biologia e Biotecnologie “Charles Darwin”, “Sapienza” Università di Roma, P.le Aldo Moro, 5, 00185 Rome, Italy; E-Mail:;Istituto di Biologia e Patologia Molecolari, CNR, P.le Aldo Moro, 5, 00185 Rome, Italy; E-Mail:;Dipartimento di Scienze Ecologiche e Biologiche Università della Tuscia Via San Camillo De Lellis, 01100 Viterbo, Italy; E-Mail:;Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, 61265 Brno, Czech Republic; E-Mail:

关键词: formamide;    nucleic bases;    uridine;    acyclonucleosides;    3';    5' cyclic nucleotides;    RNA;    RNA polymerization;    RNA origin;    ribozymes;    origin of life;   

DOI  :  10.3390/life5010372

来源: mdpi

【 摘 要 】

Reactions of formamide (NH₂COH) in the presence of catalysts of both terrestrial and meteoritic origin yield, in plausible and variegated conditions, a large panel of precursors of (pre)genetic and (pre)metabolic interest. Formamide chemistry potentially satisfies all of the steps from the very initial precursors to RNA. Water chemistry enters the scene in RNA non-enzymatic synthesis and recombination.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.