Au(I)-Catalyzed Annulation of Propargyl Amine with Aldehydes: One-Pot Cascade Synthesis of 2,5-Dimethylpyrazines

International Journal of Molecular Sciences

Ji Su¹  Huixin Liu¹  Ruimao Hua¹ 

[1] Department of Chemistry, Tsinghua University, Beijing 100084, China; E-Mails:

关键词: aldehydes;    annulation;    golden complex;    propargyl amine;    pyrazines;   

DOI  :  10.3390/ijms16023599

来源: mdpi

【 摘 要 】

3-Substituted 2,5-dimethylpyrazines were synthesized in high yields via a one-pot cascade annulation of easily available propargyl amine with aldehydes catalyzed by Au(PPh₂Cy)Cl.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.