The Actin Depolymerizing Factor (ADF)/Cofilin Signaling Pathway and DNA Damage Responses in Cancer

International Journal of Molecular Sciences

Chun-Yuan Chang¹  Jyh-Der Leu²  Yi-Jang Lee¹ 

[1] Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan; E-Mail:;Division of Radiation Oncology, Taipei City Hospital RenAi Branch, Taipei 106, Taiwan; E-Mail:

关键词: actin cytoskeleton;    ADF/cofilin;    radiosensitivity;    DDR;    radiotherapy;   

DOI  :  10.3390/ijms16024095

来源: mdpi

【 摘 要 】

The actin depolymerizing factor (ADF)/cofilin protein family is essential for actin dynamics, cell division, chemotaxis and tumor metastasis. Cofilin-1 (CFL-1) is a primary non-muscle isoform of the ADF/cofilin protein family accelerating the actin filamental turnover in vitro and in vivo. In response to environmental stimulation, CFL-1 enters the nucleus to regulate the actin dynamics. Although the purpose of this cytoplasm-nucleus transition remains unclear, it is speculated that the interaction between CFL-1 and DNA may influence various biological responses, including DNA damage repair. In this review, we will discuss the possible involvement of CFL-1 in DNA damage responses (DDR) induced by ionizing radiation (IR), and the implications for cancer radiotherapy.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.