New Insights on the Terpenome of the Red Seaweed Laurencia dendroidea (Florideophyceae, Rhodophyta)

Marine Drugs

Louisi Souza de Oliveira⁴  Diogo Antonio Tschoeke⁴  Aline Santos de Oliveira²  Lilian Jorge Hill¹  Wladimir Costa Paradas¹  Leonardo Tavares Salgado¹  Cristiane Carneiro Thompson⁴  Renato Crespo Pereira³  Fabiano L. Thompson⁴ 

[1] Research Institute of the Botanical Garden of Rio de Janeiro, Rua Pacheco Leão, 915, Jardim Botânico, Rio de Janeiro 22460-030, Brazil; E-Mails:;Federal Institute of Education, Science and Technology of Rio de Janeiro (IFRJ), Campus Duque de Caxias, Avenida República do Paraguai, 120, Sarapuí, Duque de Caxias 25050-100, Brazil; E-Mail:;Departament of Marine Biology, Federal Fluminense University (UFF), Morro do Valonguinho, s/n, Centro, Niterói 24001-970, Brazil; E-Mail:;Institute of Biology, Federal University of Rio de Janeiro (UFRJ) Av. Carlos Chagas Filho, 373-CCS-IB-BLOCO A (ANEXO) A3-202, SAGE-COPPE, Rio de Janeiro 21941-599, Brazil; E-Mails:

关键词: seaweed;    terpene synthase;    prenyl transferase;    gene;    secondary metabolite;    metabolic pathway;    mevalonate pathway;    transcriptome;    Laurencia;   

DOI  :  10.3390/md13020879

来源: mdpi

【 摘 要 】

The red seaweeds belonging to the genus Laurencia are well known as halogenated secondary metabolites producers, mainly terpenoids and acetogennins. Several of these chemicals exhibit important ecological roles and biotechnological applications. However, knowledge regarding the genes involved in the biosynthesis of these compounds is still very limited. We detected 20 different genes involved in the biosynthesis of terpenoid precursors, and 21 different genes coding for terpene synthases that are responsible for the chemical modifications of the terpenoid precursors, resulting in a high diversity of carbon chemical skeletons. In addition, we demonstrate through molecular and cytochemical approaches the occurrence of the mevalonate pathway involved in the biosynthesis of terpenes in L. dendroidea. This is the first report on terpene synthase genes in seaweeds, enabling further studies on possible heterologous biosynthesis of terpenes from L. dendroidea exhibiting ecological or biotechnological interest.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.