Inhibition of SERPINE1 Function Attenuates Wound Closure in Response to Tissue Injury: A Role for PAI-1 in Re-Epithelialization and Granulation Tissue Formation

Journal of Developmental Biology

Tessa M. Simone¹  Paul J. Higgins² 

[1] Center for Cell Biology & Cancer Research, Albany Medical College, Albany, New York, NY 12208, USA; E-Mail

关键词: SERPINE1;    PAI-1;    migration;    proliferation;    pericellular proteolysis;    tiplaxtinin;    fibrosis;    TGF-β;    wound healing;    apoptosis;   

DOI  :  10.3390/jdb3010011

来源: mdpi

【 摘 要 】

Plasminogen activator inhibitor-1 (PAI-1; SERPINE1) is a prominent member of the serine protease inhibitor superfamily (SERPIN) and a causative factor of multi-organ fibrosis as well as a key regulator of the tissue repair program. PAI-1 attenuates pericellular proteolysis by inhibiting the catalytic activity of both urokinase and tissue-type protease activators (uPA and tPA) effectively modulating, thereby, plasmin-mediated fibrinolysis and the overall pericellular proteolytic cascade. PAI-1 also impacts cellular responses to tissue injury and stress situations (growth, survival, migration) by titering the locale and temporal activation of multimeric cell-surface signaling complexes. This review will describe PAI-1 structure and function and detail the role of PAI-1 in the tissue repair program with an emphasis on cutaneous wound healing.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.