Phaleria macrocarpa Boerl. (Thymelaeaceae) Leaves Increase SR-BI Expression and Reduce Cholesterol Levels in Rats Fed a High Cholesterol Diet

Molecules

Yosie Andriani²  Tengku Sifzizul Tengku-Muhammad²  Habsah Mohamad²  Jasnizat Saidin²  Desy Fitrya Syamsumir²  Guat-Siew Chew¹  Mohd Effendy Abdul Wahid² 

[1] School of Applied and Biomedical Sciences, Faculty of Science and Technology, Federation University Australia, Ballarat, 3350 Victoria, Australia; E-Mail:;Institute of Marine Biotechnology, Universiti Malaysia Terengganu (UMT), Kuala Terengganu 21030, Terengganu, Malaysia; E-Mails:

关键词: Phaleria macrocarpa Boerl;    hypercholesterolemia;    HDL;    SR-BI;   

DOI  :  10.3390/molecules20034410

来源: mdpi

【 摘 要 】

In vitro and in vivo studies of the activity of Phaleria macrocarpa Boerl (Thymelaeaceae) leaves against the therapeutic target for hypercholesterolemia were done using the HDL receptor (SR-BI) and hypercholesterolemia-induced Sprague Dawley rats. The in vitro study showed that the active fraction (CF6) obtained from the ethyl acetate extract (EMD) and its component 2',6',4-trihydroxy-4'-methoxybenzophenone increased the SR-BI expression by 95% and 60%, respectively. The in vivo study has proven the effect of EMD at 0.5 g/kgbw dosage in reducing the total cholesterol level by 224.9% and increasing the HDL cholesterol level by 157% compared to the cholesterol group. In the toxicity study, serum glutamate oxalate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) activity were observed to be at normal levels. The liver histology also proved no toxicity and abnormalities in any of the treatment groups, so it can be categorized as non-toxic to the rat liver. The findings taken together show that P. macrocarpa leaves are safe and suitable as an alternative control and prevention treatment for hypercholesterolemia in Sprague Dawley rats.

【 授权许可】

CC BY   
©2015 by the authors; licensee MDPI, Basel, Switzerland.