Strawberry Phytochemicals Inhibit Azoxymethane/Dextran Sodium Sulfate-Induced Colorectal Carcinogenesis in Crj: CD-1 Mice

Nutrients

Ni Shi⁴  Steven K. Clinton⁴  Zhihua Liu¹  Yongquan Wang¹  Kenneth M. Riedl²  Steven J. Schwartz²  Xiaoli Zhang³  Zui Pan⁵ 

[1] State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China; E-Mails:;Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA; E-Mails:;Center for Biostatistics, The Ohio State University, Columbus, OH 43210, USA; E-Mail:;Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA; E-Mails:;Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA; E-Mail:

关键词: strawberry;    phytochemicals;    chemoprevention;    colorectal cancer;    colitis;   

DOI  :  10.3390/nu7031696

来源: mdpi

【 摘 要 】

Human and experimental colon carcinogenesis are enhanced by a pro-inflammatory microenvironment. Pharmacologically driven chemopreventive agents and dietary variables are hypothesized to have future roles in the prevention of colon cancer by targeting these processes. The current study was designed to determine the ability of dietary lyophilized strawberries to inhibit inflammation-promoted colon carcinogenesis in a preclinical animal model. Mice were given a single i.p. injection of azoxymethane (10 mg kg⁻¹ body weight). One week after injection, mice were administered 2% (w/v) dextran sodium sulfate in drinking water for seven days and then an experimental diet containing chemically characterized lyophilized strawberries for the duration of the bioassay. Mice fed control diet, or experimental diet containing 2.5%, 5.0% or 10.0% strawberries displayed tumor incidence of 100%, 64%, 75% and 44%, respectively (p < 0.05). The mechanistic studies demonstrate that strawberries reduced expression of proinflammatory mediators, suppressed nitrosative stress and decreased phosphorylation of phosphatidylinositol 3-kinase, Akt, extracellular signal-regulated kinase and nuclear factor kappa B. In conclusion, strawberries target proinflammatory mediators and oncogenic signaling for the preventive efficacies against colon carcinogenesis in mice. This works supports future development of fully characterized and precisely controlled functional foods for testing in human clinical trials for this disease.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.