Effectiveness of Dietary Allergen Exclusion Therapy on Eosinophilic Colitis in Chinese Infants and Young Children ≤ 3 Years of Age

Nutrients

Min Yang²  Lanlan Geng²  Peiyu Chen²  Fenghua Wang³  Zhaohui Xu²  Cuiping Liang²  Huiwen Li²  Tiefu Fang²  Craig A. Friesen¹  Sitang Gong² 

[1] Division of Gastroenterology, Children’s Mercy Hospitals and Clinics, Kansas City 64108, MO, USA; E-Mail:;Department of Gastroenterology, Guangzhou Women and Children’s Medical Center of Guangzhou Medical University, Guangzhou 510623, China; E-Mails:;Department of Pathology, Guangzhou Women and Children’s Medical Center of Guangzhou Medical University, Guangzhou 510623, China; E-Mail:

关键词: eosinophilic colitis;    infants;    children;    dietary exclusion;   

DOI  :  10.3390/nu7031817

来源: mdpi

【 摘 要 】

Eosinophilic colitis is a well recognized clinical entity mainly associated with food allergies. Empiric treatment options include dietary allergen exclusion (extensively hydrolyzed protein formula and elimination diet), anti-allergy medications (antihistamines and leukotriene receptor antagonists) and corticosteroids. We evaluated the effectiveness of dietary antigen exclusion on clinical remission of eosinophilic colitis in infants and young children. We retrospectively reviewed charts of all infants and children ≤3 years of age who were diagnosed with eosinophilic colitis (defined as mucosal eosinophilia ≥20 hpf⁻¹) from 1 January 2011 to 31 December 2013 at a tertiary children’s hospital in China. Forty-nine children were identified with eosinophilic colitis. Elemental formula, simple elimination diet or combination therapy resulted in clinical improvement in 75%, 88.2% and 80% of patients, respectively. In conclusion, eosinophilic colitis in infants and children ≤3 years of age responded well to dietary allergen exclusion.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.