Nutrients | |
Role of Probiotics in Short Bowel Syndrome in Infants and Children—A Systematic Review | |
Vudum S. Reddy1  Sanjay K. Patole1  | |
[1]Department of Neonatology, King Edward Memorial Hospital for Women, Subiaco, Perth, WA 6008, Australia | |
[2] E-Mail: | |
关键词: infants; children; probiotics; review; short bowel syndrome; | |
DOI : 10.3390/nu5030679 | |
来源: mdpi | |
【 摘 要 】
Short bowel syndrome (SBS) is a cause of significant morbidity and mortality in children. Probiotics, due to their beneficial effects on the gastrointestinal tract (e.g., improving gut barrier function, motility, facilitation of intestinal adaptation and decreasing pathogen load and inflammation) may have a therapeutic role in the management of SBS. To conduct a systematic review of the current evidence for the effects of probiotic supplementation in children with SBS, the standard Cochrane methodology for systematic reviews was used. The databases, Pubmed, Embase, ACTR, CENTRAL, and the international trial registry, and reference lists of articles were searched for randomised (RCT) or quasi-randomised controlled trials reporting on the use of probiotics in SBS. Our search revealed no RCTs on the use of probiotics in children with SBS. We found one small cross-over RCT (placebo controlled crossover clinical trial), one case control study and nine case reports on the use of probiotics in children with SBS. In the crossover RCT, there was no consistent effect on intestinal permeability (primary outcome) after supplementation with
【 授权许可】
CC BY
© 2013 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190038125ZK.pdf | 458KB | download |