Nano SiO2 and MgO Improve the Properties of Porous β-TCP Scaffolds via Advanced Manufacturing Technology

International Journal of Molecular Sciences

Chengde Gao¹  Pingpin Wei⁴  Pei Feng²  Tao Xiao³  Cijun Shuai²  Shuping Peng¹ 

[1] Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China; E-Mail:;State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China; E-Mail:;Orthopedic Biomedical Materials Institute, Central South University, Changsha 410083, China; E-Mail:;Cancer Research Institute, Central South University, Changsha 410078, China; E-Mail:

关键词: β-tricalcium phosphate;    SiO₂;    MgO;    selective laser sintering;    scaffolds;   

DOI  :  10.3390/ijms16046818

来源: mdpi

【 摘 要 】

Nano SiO₂ and MgO particles were incorporated into β-tricalcium phosphate (β-TCP) scaffolds to improve the mechanical and biological properties. The porous cylindrical β-TCP scaffolds doped with 0.5 wt % SiO₂, 1.0 wt % MgO, 0.5 wt % SiO₂ + 1.0 wt % MgO were fabricated via selective laser sintering respectively and undoped β-TCP scaffold was also prepared as control. The phase composition and mechanical strength of the scaffolds were evaluated. X-ray diffraction analysis indicated that the phase transformation from β-TCP to α-TCP was inhibited after the addition of MgO. The compressive strength of scaffold was improved from 3.12 ± 0.36 MPa (β-TCP) to 5.74 ± 0.62 MPa (β-TCP/SiO₂), 9.02 ± 0.55 MPa (β-TCP/MgO) and 10.43 ± 0.28 MPa (β-TCP/SiO₂/MgO), respectively. The weight loss and apatite-forming ability of the scaffolds were evaluated by soaking them in simulated body fluid. The results demonstrated that both SiO₂ and MgO dopings slowed down the degradation rate and improved the bioactivity of β-TCP scaffolds. In vitro cell culture studies indicated that SiO₂ and MgO dopings facilitated cell attachment and proliferation. Combined addition of SiO₂ and MgO were found optimal in enhancing both the mechanical and biological properties of β-TCP scaffold.

【 授权许可】

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