Enhanced Stability of Calcium Sulfate Scaffolds with 45S5 Bioglass for Bone Repair

Materials

Cijun Shuai²  Jianhua Zhou²  Ping Wu⁴  Chengde Gao²  Pei Feng²  Tao Xiao³  Youwen Deng³  Shuping Peng¹ 

[1] School of Basic Medical Science, Central South University, Changsha 410078, ChinaState Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China;Department of Orthopedics, the Second Xiangya Hospital, Central South University, Changsha 410011, China;College of Chemistry, Xiangtan University, Xiangtan 411105, China;

关键词: calcium sulfate;    45S5 bioglass;    stability;    selective laser sintering;    scaffolds;   

DOI  :  10.3390/ma8115398

来源: mdpi

【 摘 要 】

Calcium sulfate (CaSO₄), as a promising tissue repair material, has been applied widely due to its outstanding bioabsorbability and osteoconduction. However, fast disintegration, insufficient mechanical strength and poor bioactivity have limited its further application. In the study, CaSO₄ scaffolds fabricated by using selective laser sintering were improved by adding 45S5 bioglass. The 45S5 bioglass enhanced stability significantly due to the bond effect of glassy phase between the CaSO₄ grains. After immersing for four days in simulated body fluid (SBF), the specimens with 45S5 bioglass could still retain its original shape compared as opposed to specimens without 45S5 bioglass who experienced disintegration. Meanwhile, its compressive strength and fracture toughness increased by 80% and 37%, respectively. Furthermore, the apatite layer was formed on the CaSO₄ scaffolds with 45S5 bioglass in SBF, indicating good bioactivity of the scaffolds. In addition, the scaffolds showed good ability to support the osteoblast-like cell adhesion and proliferation.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.