iso-Petromyroxols: Novel Dihydroxylated Tetrahydrofuran Enantiomers from Sea Lamprey (Petromyzon marinus)

Molecules

Ke Li²  Cory O. Brant²  Ugo Bussy²  Harshita Pinnamaneni²  Hinal Patel²  Thomas R. Hoye¹  Weiming Li² 

[1] Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, MN 55455, USA; E-Mail:;Department of Fisheries and Wildlife, Michigan State University, East Lansing, MI 48824, USA; E-Mails:

关键词: stereoisomers;    relative configuration;    cyclostomata;   

DOI  :  10.3390/molecules20035215

来源: mdpi

【 摘 要 】

An enantiomeric pair of new fatty acid-derived hydroxylated tetrahydrofurans, here named iso-petromyroxols, were isolated from sea lamprey larvae-conditioned water. The relative configuration of iso-petromyroxol was elucidated with 1D and 2D NMR spectroscopic analyses. The ratio of enantiomers (er) in the natural sample was measured by chiral-HPLC-MS/MS to be ca. 3:1 of (–)- to (+)-antipodes.

【 授权许可】

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.