Ecdysonelactones, Ecdysteroids from the Tropical Eastern Pacific Zoantharian Antipathozoanthus hickmani

Marine Drugs

Paul O. Guillen¹  Karla B. Jaramillo¹  Cristobal Dominguez¹  Jenny Rodriguez¹  Grégory Genta-Jouve²  Kevin Calabro³  Olivier P. Thomas³ 

[1] Escuela Superior Politécnica del Litoral, ESPOL, Centro Nacional de Acuacultura e Investigaciones Marinas, CENAIM, Campus Gustavo Galindo km. 30.5 vía Perimetral, Guayaquil P.O. Box 09-01-5863, Ecuador;Laboratoire de Chimie-Toxicologie Analytique et Cellulaire (C-TAC) UMR CNRS 8638 COMETE, Université Paris Descartes, 4 Avenue De L’observatoire, 75006 Paris, France;Marine Biodiscovery Laboratory, School of Chemistry and Ryan Institute, National University of Ireland, Galway (NUI Galway), University Road, H91 TK33 Galway, Ireland;

关键词: ecdysteroids;    ecdysonelactones;    γ-lactone;    Zoantharia;    relative configuration;    Cnidaria;   

DOI  :  10.3390/md16020058

来源: DOAJ

【 摘 要 】

Despite a large occurrence, especially over the Pacific Ocean, the chemical diversity of marine invertebrates belonging to the order Zoantharia is largely underexplored. For the two species of the genus Antipathozoanthus no chemical study has been reported so far. The first chemical investigation of Antipathozoanthus hickmani collected at the Marine Protected Area “El Pelado”, Santa Elena, Ecuador, led to the isolation of four new ecdysteroid derivatives named ecdysonelactones. The structures of ecdysonelactones A–D (1–4) were determined based on their spectroscopy data, including 1D and 2D NMR and HRMS. The four compounds of this family of ecdysteroids feature an unprecedented γ-lactone fused at the C-2/C-3 position of ring A. These derivatives exhibited neither antimicrobial nor cytotoxic activities.

【 授权许可】

Unknown