Profiling Invasiveness in Head and Neck Cancer: Recent Contributions of Genomic and Transcriptomic Approaches

Cancers

Lluís Nisa¹  Daniel Matthias Aebersold¹  Roland Giger²  Marco Domenico Caversaccio²  Urs Borner²  Michaela Medová¹  Yitzhak Zimmer¹ 

[1] Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland; E-Mails:;Department of Otorhinolaryngology—Head and Neck Surgery, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland; E-Mails:

关键词: head and neck squamous cell carcinoma;    cell invasion;    whole exome sequencing;    gene expression profiles;    NOTCH 1;    PI3K;    epithelial-to-mesenchymal transition;   

DOI  :  10.3390/cancers7020585

来源: mdpi

【 摘 要 】

High-throughput molecular profiling approaches have emerged as precious research tools in the field of head and neck translational oncology. Such approaches have identified and/or confirmed the role of several genes or pathways in the acquisition/maintenance of an invasive phenotype and the execution of cellular programs related to cell invasion. Recently published new-generation sequencing studies in head and neck squamous cell carcinoma (HNSCC) have unveiled prominent roles in carcinogenesis and cell invasion of mutations involving NOTCH1 and PI3K-patwhay components. Gene-expression profiling studies combined with systems biology approaches have allowed identifying and gaining further mechanistic understanding into pathways commonly enriched in invasive HNSCC. These pathways include antigen-presenting and leucocyte adhesion molecules, as well as genes involved in cell-extracellular matrix interactions. Here we review the major insights into invasiveness in head and neck cancer provided by high-throughput molecular profiling approaches.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.