Evaluation of the Hypoglycemic Effects of Flavonoids and Extracts from Jatropha gossypifolia L.

Molecules

Sergio Granados¹  Norman Balcázar¹  Alis Guillén¹  Fernando Echeverri² 

[1] Grupo de Genética Molecular y Departamento de Fisiología y Bioquímica, Facultad de Medicina, Universidad de Antioquia, Calle 67 No. 53-10, Medellín 050010, Colombia; E-Mails:;Grupo de Quimica Orgánica de Productos Naturales, Instituto de Química, Universidad de Antioquia, Calle 67 No. 53-10, Medellín 050010, Colombia

关键词: Jatropha gossypifolia L.;    flavanone;    flavone;    glucose regulation;    myotubes;    mice;   

DOI  :  10.3390/molecules20046181

来源: mdpi

【 摘 要 】

Jatropha gossypifolia L. (Euphorbiaceae) is a plant widely used in the treatment of type 2 diabetes mellitus (T2DM), but there are few scientific reports validating its activity in this area. In this work and through a bioguided assay, a crude extract stimulated glucose uptake in C2C12 myotubes up to 30%, thereby reducing insulin resistance induced by fatty acids compared to the basal control. A chromatographic fraction applied intraperitoneally (IP) in mice reduced glucose by 42% in a mouse model of T2DM, after administration of 10 doses during 20 days. A flavanone was purified from this active fraction and its structure was assigned by ¹H- and ¹³C-NMR (1D and 2D) and MS. This compound retains the previously reported activity, stimulating in vitro the glucose uptake in a concentration-dependent manner. This study indicates that Jatropha gossypifolia L. extracts enhance glucose uptake in cultured myotubes and adipocytes and also improving glucose tolerance in an in vivo model.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.