Marine Natural Products as Breast Cancer Resistance Protein Inhibitors

Marine Drugs

Lilia Cherigo¹  Dioxelis Lopez²  Sergio Martinez-Luis³ 

[1] Department of Organic Chemistry, Chemistry School, Faculty of Natural Sciences, Exact and Technology, University of Panama, Panama City P.O. Box 3366, Panama; E-Mail:;Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, India; E-Mail:;Center for Drug Discovery and Biodiversity, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, Panama City P.O. Box 0843-01103, Panama

关键词: marine natural products;    ABC transporters;    breast cancer resistance protein (BCRP);    multidrug resistance (MDR);   

DOI  :  10.3390/md13042010

来源: mdpi

【 摘 要 】

Breast cancer resistance protein (BCRP) is a protein belonging to the ATP-binding cassette (ABC) transporter superfamily that has clinical relevance due to its multi-drug resistance properties in cancer. BCRP can be associated with clinical cancer drug resistance, in particular acute myelogenous or acute lymphocytic leukemias. The overexpression of BCRP contributes to the resistance of several chemotherapeutic drugs, such as topotecan, methotrexate, mitoxantrone, doxorubicin and daunorubicin. The Food and Drugs Administration has already recognized that BCRP is clinically one of the most important drug transporters, mainly because it leads to a reduction of clinical efficacy of various anticancer drugs through its ATP-dependent drug efflux pump function as well as its apparent participation in drug resistance. This review article aims to summarize the different research findings on marine natural products with BCRP inhibiting activity. In this sense, the potential modulation of physiological targets of BCRP by natural or synthetic compounds offers a great possibility for the discovery of new drugs and valuable research tools to recognize the function of the complex ABC-transporters.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.