期刊论文详细信息
International Journal of Molecular Sciences | |
Design of an Osteoinductive Extracellular Fibronectin Matrix Protein for Bone Tissue Engineering | |
Sujin Lee2  Dong-Sung Lee1  Ilsan Choi2  Le B. Hang Pham2  Jun-Hyeog Jang2  | |
[1] Department of Biomedical Chemistry, Konkuk University, Chung-Ju 380-701, Korea; E-Mail:;Department of Biochemistry, College of Medicine, Inha University, Incheon 400-712, Korea; E-Mails: | |
关键词: bone morphogenetic protein; cell adhesion; cell differentiation; fibronectin; MC3T3 cells; | |
DOI : 10.3390/ijms16047672 | |
来源: mdpi | |
【 摘 要 】
Integrin-mediated cell-matrix interactions play an important role in osteogenesis. Here, we constructed a novel osteoinductive fibronectin matrix protein (oFN) for bone tissue engineering, designed to combine the integrin-binding modules from fibronectin (iFN) and a strong osteoinductive growth factor, bone morphogenetic protein-2. Compared with iFN, the purified oFN matrix protein caused a significant increase in cell adhesion and osteogenic differentiation of pre-osteoblast MC3T3-E1 cells (
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190014124ZK.pdf | 1120KB | download |