期刊论文详细信息
International Journal of Molecular Sciences
Design of an Osteoinductive Extracellular Fibronectin Matrix Protein for Bone Tissue Engineering
Sujin Lee2  Dong-Sung Lee1  Ilsan Choi2  Le B. Hang Pham2  Jun-Hyeog Jang2 
[1] Department of Biomedical Chemistry, Konkuk University, Chung-Ju 380-701, Korea; E-Mail:;Department of Biochemistry, College of Medicine, Inha University, Incheon 400-712, Korea; E-Mails:
关键词: bone morphogenetic protein;    cell adhesion;    cell differentiation;    fibronectin;    MC3T3 cells;   
DOI  :  10.3390/ijms16047672
来源: mdpi
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【 摘 要 】

Integrin-mediated cell-matrix interactions play an important role in osteogenesis. Here, we constructed a novel osteoinductive fibronectin matrix protein (oFN) for bone tissue engineering, designed to combine the integrin-binding modules from fibronectin (iFN) and a strong osteoinductive growth factor, bone morphogenetic protein-2. Compared with iFN, the purified oFN matrix protein caused a significant increase in cell adhesion and osteogenic differentiation of pre-osteoblast MC3T3-E1 cells (p < 0.05).

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.

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