Organic-Inorganic Hybrid Nanoparticles for Bacterial Inhibition: Synthesis and Characterization of Doped and Undoped ONPs with Ag/Au NPs

Molecules

Carlos Alberto Huerta Aguilar²  Adriana Berenice Pérez Jiménez²  Antonio Romero Silva²  Navneet Kaur³  Pandiyan Thangarasu²  Jorge Manuel Vázquez Ramos²  Narinder Singh¹ 

[1] Department of Chemistry, Indian Institute of Technology Ropar, Rupnagar, Panjab 140001, India; E-Mail:;Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Coyoacán, 04510 México D.F., Mexico; E-Mails:;Centre for Nanoscience & Nanotechnology, Panjab University, Chandigarh, Panjab 160014, India; E-Mail:

关键词: antibacterial studies;    organic nanoparticles;    lipoic acid;    Staphylococcus aureus;    Bacillus cereus;    Escherichia coli;    Salmonella typhi;   

DOI  :  10.3390/molecules20046002

来源: mdpi

【 摘 要 】

Organic nanoparticles (ONPs) of lipoic acid and its doped derivatives ONPs/Ag and ONPs/Au were prepared and characterized by UV-Visible, EDS, and TEM analysis. The antibacterial properties of the ONPs ONPs/Ag and ONPs/Au were tested against bacterial strains (Staphylococcus aureus, Bacillus cereus, Escherichia coli and Salmonella typhi). Minimal Inhibitory Concentration (MIC) and bacterial growth inhibition tests show that ONPs/Ag are more effective in limiting bacterial growth than other NPs, particularly, for Gram positive than for Gram-negative ones. The order of bacterial cell growth inhibition was ONPs/Ag > ONPs > ONPs/Au. The morphology of the cell membrane for the treated bacteria was analyzed by SEM. The nature of bond formation of LA with Ag or Au was analyzed by molecular orbital and density of state (DOS) using DFT.

【 授权许可】

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