Anti-Inflammatory Effect ofEmodin via Attenuation of NLRP3 Inflammasome Activation

International Journal of Molecular Sciences

Ji-Won Han²  Do-Wan Shim²  Woo-Young Shin²  Kang-Hyuk Heo²  Su-Bin Kwak²  Eun-Jeong Sim²  Jae-Hyun Jeong¹  Tae-Bong Kang²  Kwang-Ho Lee² 

[1] Department of Food Science & Technology, Korea National University of Transportation, Chungju 368-701, Korea; E-Mail:;Department of Biotechnology, College of Biomedical & Health Science, Research Institute of Inflammatory Diseases, Konkuk University, Chungju 380-701, Korea; E-Mails:

关键词: emodin;    interleukin (IL)-1β;    NLRP3 inflammasome;    sepsis;   

DOI  :  10.3390/ijms16048102

来源: mdpi

【 摘 要 】

Emodin, an active constituent of oriental herbs, is widely used to treat allergy, inflammation, and other symptoms. This study provides the scientific basis for the anti-inflammasome effects of emodin on both in vitro and in vivo experimental models. Bone marrow-derived macrophages were used to study the effects of emodin on inflammasome activation by using inflammasome inducers such as ATP, nigericin, and silica crystals. The lipopolysaccharide (LPS)-induced endotoxin shock model was employed to study the effect of emodin on in vivo efficacy. Emodin treatment attenuated interleukin (IL)-1β secretion via the inhibition of NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation induced by ATP, nigericin, and silica crystals. Further, emodin ameliorated the severity of NLRP3 inflammasome-mediated symptoms in LPS-induced endotoxin mouse models. This study is the first to reveal mechanism-based evidence, especially with respect to regulation of inflammasome activation, substantiating traditional claims of emodin in the treatment of inflammation-related disorders.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.