Encapsulated Cellular Implants for Recombinant Protein Delivery and Therapeutic Modulation of the Immune System

International Journal of Molecular Sciences

Aurélien Lathuilière³  Nicolas Mach²  Bernard L. Schneider¹ 

[1] Neurodegenerative Studies Laboratory, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland;Department of Oncology, Geneva University Hospital and Medical School, 1205 Geneva, Switzerland; E-Mail:;Division of Neurology, Department of clinical Neuroscience, Geneva University Hospitals, 1205 Geneva, Switzerland; E-Mail:

关键词: cellular implants;    genetic engineering;    encapsulation;    passive immunization;    recombinant antibodies;    Alzheimer’s disease;    cytokine;    adjuvant;    cancer vaccine;   

DOI  :  10.3390/ijms160510578

来源: mdpi

【 摘 要 】

Ex vivo gene therapy using retrievable encapsulated cellular implants is an effective strategy for the local and/or chronic delivery of therapeutic proteins. In particular, it is considered an innovative approach to modulate the activity of the immune system. Two recently proposed therapeutic schemes using genetically engineered encapsulated cells are discussed here: the chronic administration of monoclonal antibodies for passive immunization against neurodegenerative diseases and the local delivery of a cytokine as an adjuvant for anti-cancer vaccines.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.