Skeletal Muscle Mitochondrial Energetic Efficiency and Aging

International Journal of Molecular Sciences

Raffaella Crescenzo²  Francesca Bianco²  Arianna Mazzoli²  Antonia Giacco²  Giovanna Liverini²  Susanna Iossa¹ 

[1] Department of Biology, University of Naples “Federico II”, Napoli I-80126, Italy;

关键词: mitochondria;    aging;    skeletal muscle;    proton leak;   

DOI  :  10.3390/ijms160510674

来源: mdpi

【 摘 要 】

Aging is associated with a progressive loss of maximal cell functionality, and mitochondria are considered a key factor in aging process, since they determine the ATP availability in the cells. Mitochondrial performance during aging in skeletal muscle is reported to be either decreased or unchanged. This heterogeneity of results could partly be due to the method used to assess mitochondrial performance. In addition, in skeletal muscle the mitochondrial population is heterogeneous, composed of subsarcolemmal and intermyofibrillar mitochondria. Therefore, the purpose of the present review is to summarize the results obtained on the functionality of the above mitochondrial populations during aging, taking into account that the mitochondrial performance depends on organelle number, organelle activity, and energetic efficiency of the mitochondrial machinery in synthesizing ATP from the oxidation of fuels.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.