Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications

Sensors

Hoang Hiep Nguyen²  Jeho Park²  Sebyung Kang¹  Moonil Kim² 

[1] Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 689-798, Korea;BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-806, Korea; E-Mails:

关键词: surface plasmon resonance;    SPR;    biosensor;    SPR imaging;    applications;   

DOI  :  10.3390/s150510481

来源: mdpi

【 摘 要 】

Surface plasmon resonance (SPR) is a label-free detection method which has emerged during the last two decades as a suitable and reliable platform in clinical analysis for biomolecular interactions. The technique makes it possible to measure interactions in real-time with high sensitivity and without the need of labels. This review article discusses a wide range of applications in optical-based sensors using either surface plasmon resonance (SPR) or surface plasmon resonance imaging (SPRI). Here we summarize the principles, provide examples, and illustrate the utility of SPR and SPRI through example applications from the biomedical, proteomics, genomics and bioengineering fields. In addition, SPR signal amplification strategies and surface functionalization are covered in the review.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.