Recent advances in surface plasmon resonance imaging: detection speed, sensitivity, and portability

Nanophotonics

article

Youjun Zeng¹  Bruce Zhi Gao²  Yonghong Shao¹  Rui Hu¹  Lei Wang¹  Dayong Gu³  Jianan He³  Shu-Yuen Wu⁴  Ho-Pui Ho⁴  Xuejin Li¹  Junle Qu¹ 

[1] Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen Key Laboratory of Sensor Technology, Shenzhen University;Department of Bioengineering and COMSET, Clemson University;Shenzhen Entry-exit Inspection and Quarantine Bureau;Department of Electronic Engineering, The Chinese University of Hong Kong

关键词: biosensors;    surface plasmon resonance;    SPR imaging;    nanoplasmonics;    plasmonics;   

DOI  :  10.1515/nanoph-2017-0022

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

Surface plasmon resonance (SPR) biosensor is a powerful tool for studying the kinetics of biomolecular interactions because they offer unique real-time and label-free measurement capabilities with high detection sensitivity. In the past two decades, SPR technology has been successfully commercialized and its performance has continuously been improved with lots of engineering efforts. In this review, we describe the recent advances in SPR technologies. The developments of SPR technologies focusing on detection speed, sensitivity, and portability are discussed in details. The incorporation of imaging techniques into SPR sensing is emphasized. In addition, our SPR imaging biosensors based on the scanning of wavelength by a solid-state tunable wavelength filter are highlighted. Finally, significant advances of the vast developments in nanotechnology-associated SPR sensing for sensitivity enhancements are also reviewed. It is hoped that this review will provide some insights for researchers who are interested in SPR sensing, and help them develop SPR sensors with better sensitivity and higher throughput.

【 授权许可】

CC BY