International Journal of Molecular Sciences | |
5-ALA Fluorescence Image Guided Resection of Glioblastoma Multiforme: A Meta-Analysis of the Literature | |
Samy Eljamel1  | |
[1] Neurological Surgery, High Tech Neuro & Micro Surgery, Edinburgh EH3 8JB, UK; E-Mail | |
关键词: ALA; FIGS; FIGR; glioma; glioblastoma; brain tumor; surgery; | |
DOI : 10.3390/ijms160510443 | |
来源: mdpi | |
【 摘 要 】
Background: Glioblastoma multiforme (GBM) is one of the most deadly cancers in humans. Despite recent advances in anti-cancer therapies, most patients with GBM die from local disease progression. Fluorescence image guided surgical resection (FIGR) was recently advocated to enhance local control of GBM. This is meta-analyses of 5-aminolevulinic (5-ALA) induced FIGR. Materials: Review of the literature produced 503 potential publications; only 20 of these fulfilled the inclusion criteria of this analysis, including a total of 565 patients treated with 5-ALA-FIGR reporting on its outcomes and 800 histological samples reporting 5-ALA-FIGR sensitivity and specificity. Results: The mean gross total resection (GTR) rate was 75.4% (95% CI: 67.4–83.5,
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190012675ZK.pdf | 4374KB | download |