Molecules | |
Novel All Trans-Retinoic Acid Derivatives: Cytotoxicity, Inhibition of Cell Cycle Progression and Induction of Apoptosis in Human Cancer Cell Lines | |
Ebtesam Saad Al-Sheddi1  Mai Mohammad Al-Oqail1  Quaiser Saquib2  Maqsood Ahmed Siddiqui2  Javed Musarrat2  Abdulaziz Ali Al-Khedhairy2  Nida Nayyar Farshori1  | |
[1] Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia; E-Mails:;Zoology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; E-Mails: | |
关键词: all trans-retinoic acid; anticancer activity; apoptosis; cell cycle arrest; cytotoxicity; | |
DOI : 10.3390/molecules20058181 | |
来源: mdpi | |
【 摘 要 】
Owing to the pharmacological potential of ATRA (all trans-retinoic acid), a series of retinamides and a 1-(retinoyl)-1,3-dicyclohexylurea compound were prepared by reacting ATRA with long chain alkyl or alkenyl fatty amines by using a 4-demethylaminopyridine (DMAP)-catalyzed
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190012654ZK.pdf | 3436KB | download |