Almond Skin Inhibits HSV-2 Replication in Peripheral Blood Mononuclear Cells by Modulating the Cytokine Network

Molecules

Adriana Arena²  Carlo Bisignano³  Giovanna Stassi²  Angela Filocamo¹  Giuseppina Mandalari¹ 

[1] Department of Drug Science and Products for Health, Vill. SS. Annunziata, Messina 98100, Italy; E-Mail:;Department of Human Pathology, Policlinico Universitario, Via C. Valeria, Messina 98125, Italy; E-Mails:;Department of Biological and Environmental Science, University of Messina, Sal. Sperone 31, Messina 98100, Italy; E-Mail:

关键词: HSV-2;    cytokines;    IL-17;    almond skins;   

DOI  :  10.3390/molecules20058816

来源: mdpi

【 摘 要 】

We have investigated the effect of almond skin extracts on the production of pro-inflammatory and anti-inflammatory cytokines in human peripheral blood mononuclear cells (PBMCs). PBMCs were either infected or not by herpes simplex virus type 2 (HSV-2), with and without prior treatment with almond skin extracts. Production of IL-17 induced by HSV-2 was inhibited by natural skins (NS) treatment. NS triggered PBMC in releasing IFN-α, IFN-γ and IL-4 in cellular supernatants. These results may explain the antiviral potential of almond skins.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.