Improved Blood Biomarkers but No Cognitive Effects from 16 Weeks of Multivitamin Supplementation in Healthy Older Adults

Nutrients

Elizabeth Harris¹  Helen Macpherson¹ 

[1] Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia; E-Mails:

关键词: multivitamins;    vitamins;    cognition;    biomarkers;   

DOI  :  10.3390/nu7053796

来源: mdpi

【 摘 要 】

Supplementation with vitamins, minerals and phytonutrients may be beneficial for cognition, especially in older adults. The aim of this study was to assess the effects of multivitamin supplementation in older adults on cognitive function and associated blood biomarkers. In a randomised, double blind, placebo-controlled trial, healthy women (n = 68) and men (n = 48) aged 55–65 years were supplemented daily for 16 weeks with women’s and men’s formula multivitamin supplements. Assessments at baseline and post-supplementation included computerised cognitive tasks and blood biomarkers relevant to cognitive aging. No cognitive improvements were observed after supplementation with either formula; however, several significant improvements were observed in blood biomarkers including increased levels of vitamins B₆ and B₁₂ in women and men; reduced C-reactive protein in women; reduced homocysteine and marginally reduced oxidative stress in men; as well as improvements to the lipid profile in men. In healthy older people, multivitamin supplementation improved a number of blood biomarkers that are relevant to cognition, but these biomarker changes were not accompanied by improved cognitive function.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.