Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp.

Marine Drugs

Chin-Soon Phan²  Shean-Yeaw Ng²  Eun-A Kim¹  You-Jin Jeon¹  Kishneth Palaniveloo²  Charles Santhanaraju Vairappan² 

[1] Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Korea; E-Mail:;Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia; E-Mails:

关键词: soft coral;    Capnella sp.;    Nephtheidae;    sesquiterpenoids;    bicyclogermacrene;   

DOI  :  10.3390/md13053103

来源: mdpi

【 摘 要 】

Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulation of the LPS-induced pro-inflammatory IL-1β and NO production by down-regulating the expression of iNOS protein in RAW 264.7 macrophages.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.